Maritime Cultural Heritage and Urbanisation in the Middle East and North Africa

Urbanisation, comprising development, land reclamation and population growth along coastal margins, continues to place significant pressure on the maritime cultural heritage (MCH), particularly in the Middle East and North Africa (MENA) region. Thus, there is a growing need for ascertaining the extent of the affected MCH resource and its condition. One such assessment is being undertaken by the Maritime Endangered Archaeology (MarEA) project, which is generating a unique informed database of the maritime resource in the MENA region. Through a regional overview combined with focused assessment on two case studies – Marsa Matruh (Egypt) and Bahrain – this paper demonstrates the threat urbanisation poses and the damage it has inflicted on MCH. The analyses and documentation that MarEA produces via remote sensing, deskbased and field-based assessments, constitutes a valuable resource that, at the very least, exists in digital perpetuity. It establishes a record that can be drawn upon to formulate targeted strategies and initiatives inclusive of the maritime cultural heritage resource

Maritime Cultural Heritage and Urbanisation in the Middle East and North Africa

Urbanisation, comprising development, land reclamation and population growth along coastal margins, continues to place significant pressure on the maritime cultural heritage (MCH), particularly in the Middle East and North Africa (MENA) region. Thus, there is a growing need for ascertaining the extent of the affected MCH resource and its condition. One such assessment is being undertaken by the Maritime Endangered Archaeology (MarEA) project, which is generating a unique informed database of the maritime resource in the MENA region. Through a regional overview combined with focused assessment on two case studies – Marsa Matruh (Egypt) and Bahrain – this paper demonstrates the threat urbanisation poses and the damage it has inflicted on MCH. The analyses and documentation that MarEA produces via remote sensing, deskbased and field-based assessments, constitutes a valuable resource that, at the very least, exists in digital perpetuity. It establishes a record that can be drawn upon to formulate targeted strategies and initiatives inclusive of the maritime cultural heritage resource

Maritime endangered archaeology of the Middle East and North Africa: the MarEA project

The ‘Maritime Endangered Archaeology’ (MarEA) project is conducting remote, large-scale identification and assessment of vulnerable maritime heritage to assist in its management in the face of challenges such as climate change and rapid urbanisation

Documenting, protecting and managing endangered maritime cultural heritage in the Middle East and North Africa (MENA) region

For millennia, the Middle East and North Africa (MENA) region has been a culturally dynamic zone, bounded by maritime societies dependent on the sea for communication, trade and livelihoods. The archaeological evidence of these past societies represents an extraordinary physical legacy of human endeavour and presence across this region, contributing to senses of place, identity and belonging amongst contemporary coastal communities. However, the coastal landscapes and marine environment of the MENA region are undergoing a period of profound change, associated with large-scale human development and climate change. In order to assess this change and the level of impact on the resource, the Maritime Endangered Archaeology project (MarEA) was established in 2019 to document cultural heritage sites and landscapes across the coastal and near-shore zones of the survey region. This paper introduces the work of the project and outlines a series of case studies presented in this volume that are representative of the variety and depth of work being undertaken within the project

Animal Models of Rheumatoid Arthritis

Autoimmunity is a condition in which the host organizes an immune response against its own antigens. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, characterized by the presence of chronic inflammatory infiltrates, the development of destructive arthropathy, bone erosion, and degradation of the articular cartilage and subchondral bone. There is currently no treatment that resolves the disease, only the use of palliatives, and not all patients respond to pharmacologic therapy. According to RA multifactorial origin, several in vivo models have been used to evaluate its pathophysiology as well as to identify the usefulness of biomarkers to predict, to diagnose, or to evaluate the prognosis of the disease. This chapter focuses on the most common in vivo models used for the study of RA, including those related with genetic, immunological, hormonal, and environmental interactions. Similarly, the potential of these models to understand RA pathogenesis and to test preventive and therapeutic strategies of autoimmune disorder is also highlighted. In conclusion, of all the animal models discussed, the CIA model could be considered the most successful by generating arthritis using type II collagen and adjuvants and evaluating therapeutic compounds both intra-articularly and systemically

High-flow nasal cannula therapy for hypoxemic respiratory failure in patients with COVID-19.

INTRODUCTION: High-flow nasal cannula (HFNC) therapy in patients with hypoxemic respiratory failure due to COVID-19 is poorly understood and remains controversial. METHODS: We evaluated a large cohort of patients with COVID-19-related hypoxemic respiratory failure at the temporary COVID-19 hospital in Mexico City. The primary outcome was the success rate of HFNC to prevent the progression to invasive mechanical ventilation (IMV). We also evaluated the risk factors associated with HFNC success or failure. RESULTS: HFNC use effectively prevented IMV in 71.4% of patients [270 of 378 patients; 95% confidence interval (CI) 66.6-75.8%]. Factors that were significantly different at admission included age, the presence of hypertension, and the Charlson comorbidity index. Predictors of therapy failure (adjusted hazard ratio, 95% CI) included the comorbidity-age-lymphocyte count-lactate dehydrogenase (CALL) score at admission (1.27, 1.09-1.47; p < 0.01), Rox index at 1 hour (0.82, 0.7-0.96; p = 0.02), and no prior steroid treatment (0.34, 95% CI 0.19-0.62; p < 0.0001). Patients with HFNC success rarely required admission to the intensive care unit and had shorter lengths of hospital stay [19/270 (7.0%) and 15.0 (interquartile range, 11-20) days, respectively] than those who required IMV [104/108 (96.3%) and 26.5 (20-36) days, respectively]. CONCLUSION: Treating patients with HFNC at admission led to improvement in respiratory parameters in many patients with COVID-19

International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures

Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries